Erectile dysfunction medications such as sildenafil (Cenforce), tadalafil (Vidalista), vardenafil (Vilitra) and avanafil (Avana) are among today’s most commonly used prescription drugs.
These are also some of the most well-understood, with a large number of studies observing direct effects, side effects, their typical initiation of action, half-life, and other important factors influencing how each drug affects the body.
Below, we discussed what to expect from erectile dysfunction medication, how long to wait before the drug takes effect on the side effects you might experience as a result of the medication.
We have presented data to help you compare the four ED medications currently on the market directly, ranging from well-known alternatives such as sildenafil (Cenforce) to newer erectile dysfunction treatments such as avanafil (Avana).
ED Medication Action onset: How long does it take?
It takes 30 to 60 minutes for most erectile dysfunction medications to start working. The fastest-acting ED drug is avanafil (Avana), which can begin to cause noticeable effects in 15 minutes if the medicine is used in a moderate to high dosage.
Sildenafil, or Viagra, takes about an hour to start working and should be taken about 60 minutes before having sex. Most of the time, after being taken orally, a typical dose of sildenafil can begin to produce a noticeable effect between 30 and 60 minutes.
Tadalafil, or Vidalista, takes between 30 and 60 minutes to start working, although if you take a high dose of the drug, particularly on an empty stomach, it can begin to produce noticeable effects in as little as 15 minutes.
Eventually, in about the same amount of time as sildenafil, vardenafil, or Vilitra, take action. Most vardenafil manufacturers recommend taking the drug approximately 60 minutes before sexual activity to give it time to start working.
It’s best to take your ED medication about an hour before you decide to have sex, regardless of the specific drug you use. Prepare ahead of time and you will experience the full effects of the drug when you become involved with your partner.
As always, it is important to follow their advice if your doctor gives a specific recommendation when to take your medication.
All four of the above-mentioned ED drugs can be used with or without food. If you eat a large meal with a high-fat content before taking any of the above-mentioned ED medications, the amount of time needed for the medication to start working may be increased.
For this reason, most manufacturers of ED drugs recommend taking sildenafil, tadalafil, vardenafil, or avanafil with a glass of water on a relatively empty stomach (or after a regular meal).
Half-Lives of ED Medications: How Long Does it Last?
The half-life of a drug is the amount of time it takes for your body to absorb the product to fall to half its height. For example, after a half-life has passed, a typical 50 mg dose of sildenafil (Cenforce) will be reduced to the potency of about 25 mg.
A medication’s half-life determines how long it will stay active in the body. Generally, after a half-life, ED drugs still produce some effects and gradually become less effective as they are eliminated from the body and excreted.
The drug will be completely ineffective after two or three half-lives have passed and will not provide any noticeable effects.
The half-lives and duration of action for all four of the most popular ED drugs are described below:
- Sildenafil (Cenforce) has a half-life of four hours and remains active in the body for three to five hours after it is consumed as an effective erectile dysfunction treatment. Usually, sildenafil will not provide any noticeable benefits after five hours have passed.
- Tadalafil (Vidalista) has a half-life of 17.5 hours and remains active in the body as an effective treatment for erectile dysfunction up to 36 hours after consumption. This has earned a reputation for treating ED as a “weekend pill.” Buy Vidalista 20mg online our EMG online pharmacy at a low price.
- Vardenafil (Vilitra), has a four to five-hour half-life and remains active in the body for up to six hours after ingestion. It gives it an impact that is slightly longer than sildenafil.
- Avanafil (Avana) has a five-hour half-life and remains active in the body for up to 6 hours after consumption. This gives it an effect period similar to vardenafil and a half-life slightly longer than sildenafil.
Tadalafil, as you can see, is by far the longest-lasting of the four medications currently on the market.
For this reason, tadalafil is typically the best option for men who want to handle ED at once for several days without having to take multiple tablets of their ED medication. It is generally preferred for occasional use to use shorter-acting medications such as sildenafil, vardenafil, and avanafil.
The potential advantage of treating benign prostatic hyperplasia (BPH) is also tadalafil. Of course, you should always talk to your doctor about using tadalafil to treat either erectile dysfunction or BPH.
7 Common Side Effects of ED Medication
According to the similar work of most ED medications, they also have similar side effects. Usually, the side effects of ED drugs arise while the drugs are active in the body, although in some instances the side effects of ED drugs may last slightly longer than the drug itself.
That means that if you are susceptible to side effects from ED medications if you use medicine like tadalafil that has a very long half-life, you can find it lasting longer.
Common side effects of ED drugs are:
Headaches, associated with all medications for ED. Headaches are most often caused by increased levels of nitric oxide that may increase blood flow and lead to a temporary headache.
Dizziness, also due to increased levels of nitric oxide. Usually, dizziness from ED medication is not extreme but may lead to pain and fainting in people with underlying health conditions.
Muscle aches, that can also be caused by the increase in blood flow from all widely available ED medicines.
Nasal congestion, or a stuffy nose. It typically occurs when there is a high concentration of ED medications and reverses as the narcotics are metabolized and excreted.
Facial flush, which varies from slight redness of the face to bright red lips, which seems to be infected by a rash. It typically reverses, like other side effects, as the drug rates in your body decrease.
Vision issues, including intermittent blurred vision and blue-tinted vision. This condition is called cyanopsia and is thought to be the result of decreased activity of the enzyme.
Digestive issues, ranging from vomiting to bloating and indigestion. Generally, these are acute and can be made worse by consuming alcohol, caffeine, carbonated beverages, and dairy products.
Avanafil is more selective in the tissue it is aiming for as a second-generation ED medication. This means that some side effects, such as changes in vision and certain cardiovascular effects, are less likely than older medications.
If you have cardiovascular health problems, some of the side effects, such as headaches and dizziness, are particularly important.
All of the currently available ED drugs will cause a slight decrease in blood pressure levels. This is caused by their effects on blood flow and smooth muscle tissue. This decrease is mild in healthy men and does not cause any dangerous side effects.
Nevertheless, if you use nitrates or other drugs to treat hypertension, it can be dangerous to reduce blood pressure induced by ED medications. You must not use sildenafil, tadalafil, vardenafil, avanafil or any other similar drugs if you use any nitrates.
The drug guide for men with heart disease describes in more depth these reactions and consequences, as well as what you can do to treat erectile dysfunction safely if you take medication to treat an underlying cardiovascular disorder.
Depending on a variety of factors, the cost of treating erectile dysfunction with commonly prescribed drugs such as sildenafil, tadalafil, vardenafil, and avanafil may vary.
The first element is the dose that you are using. Most ED medicines come in a range of doses, which means that one person’s effective dose may not be equal to another person’s effective dose. Your primary care doctor can help you determine the dose you should use.
The second factor is the drug you’re using. The different drugs available at different prices are sildenafil, tadalafil, vardenafil, and avanafil.
The third factor is how much medicine you are using. The cost will quickly add up if you use ED medicine every day; if you take it once or twice a week, the total cost per year will be much smaller.
Your insurance coverage is the fourth factor. While some insurance policies do not cover the cost of ED treatment, others do so, greatly lowering the cost of treating erectile dysfunction.
Finally, the brand of medication you choose is an important cost factor. Most ED medicines are sold as licensed medicines like Sildenafil, Tadalafil, and Vardenafil, but are also available as generic medicines at much more affordable prices.